Delta Sleep-Inudcing Peptide (DSIP) Benefits: Found in Research
Share
Delta sleep-inducing peptide (DSIP) has been studied for its potential benefits in various contexts, particularly related to sleep and stress regulation.
1. Sleep Promotion: DSIP has shown promise in promoting sleep and improving sleep architecture. Studies have demonstrated that DSIP can enhance non-rapid eye movement (NREM) and rapid eye movement (REM) sleep, which are crucial for restorative sleep. For instance, phosphorylated DSIP (p-DSIP) was found to improve sleep architecture and restore spatial memory in rats exposed to high altitude hypoxia. Additionally, DSIP fusion peptides have been shown to modulate neurotransmitter levels and enhance sleep in insomnia models.[1-2]
2. Stress Protection: DSIP has been implicated in stress protection by modulating oxidative phosphorylation and ATP production in mitochondria. It has been shown to enhance mitochondrial respiratory efficiency and protect against hypoxia-induced stress in rat brain mitochondria. Furthermore, DSIP administration has been associated with the normalization of prooxidant-antioxidant balance under cold stress conditions.[3-4]
4. Antiepileptic Activity: DSIP and its analogues have shown antiepileptic properties in animal models, reducing the incidence and severity of seizures.[6]
5. Aging and Cancer: DSIP-containing preparations like Deltaran have been reported to decrease spontaneous tumor incidence and extend the lifespan of mice, suggesting potential geroprotective and anticarcinogenic effects.[7]
In summary, DSIP offers potential benefits in sleep promotion, stress protection, neuroprotection, antiepileptic activity, and possibly in aging and cancer prevention. These effects are supported by various studies, highlighting its multifaceted role in physiological regulation.
1. Phosphorylated Delta Sleep Inducing Peptide Restores Spatial Memory and P-Creb Expression by Improving Sleep Architecture at High Altitude. Roy K, Chauhan G, Kumari P, et al. Life Sciences. 2018;209:282-290. doi:10.1016/j.lfs.2018.08.026.
2. Pichia Pastoris Secreted Peptides Crossing the Blood-Brain Barrier and DSIP Fusion Peptide Efficacy in PCPA-induced Insomnia Mouse Models.
Mu X, Qu L, Yin L, et al. Frontiers in Pharmacology. 2024;15:1439536. doi:10.3389/fphar.2024.1439536.
New Research
3. Delta Sleep Inducing Peptide (DSIP): Effect on Respiration Activity in Rat Brain Mitochondria and Stress Protective Potency Under Experimental Hypoxia.
Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II. Peptides. 2003;24(2):307-11. doi:10.1016/s0196-9781(03)00040-8.
4. Regulation of Free Radical Processes by Delta-Sleep Inducing Peptide in Rat Tissues Under Cold Stress. Shustanova TA, Bondarenko TI, Milyutina NP, Mikhaleva II. Biochemistry. Biokhimiia. 2001;66(6):632-9. doi:10.1023/a:1010255230338.
5. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats After Focal Stroke.
Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, et al. Molecules (Basel, Switzerland). 2021;26(17):5173. doi:10.3390/molecules26175173.
6. Antiepileptic Activity of Delta Sleep-Inducing Peptide and Its Analogue in Metaphit-Provoked Seizures in Rats. Stanojlović OP, Zivanović DP, Mirković SD, Mikhaleva II. Seizure. 2005;14(4):240-7. doi:10.1016/j.seizure.2005.02.001.
7. Effect of Delta-Sleep Inducing Peptide-Containing Preparation Deltaran on Biomarkers of Aging, Life Span and Spontaneous Tumor Incidence in Female SHR Mice.
Popovich IG, Voitenkov BO, Anisimov VN, et al. Mechanisms of Ageing and Development. 2003;124(6):721-31. doi:10.1016/s0047-6374(03)00082-4.