Epitalon Peptide Benefits in Research
Share
Epitalon, also known as Epithalon or Epithalone, is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland peptide Epithalamin. It has been studied for its potential geroprotective and neuroendocrine effects.
Epitalon has demonstrated several potential benefits:
1. Antioxidant Properties: Epitalon has been shown to possess significant antioxidant properties, which may exceed those of melatonin. It enhances the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase, contributing to its geroprotective effects.[1]
2. Telomerase Activation: Epitalon has been found to activate telomerase, an enzyme that extends telomeres, thereby potentially delaying cellular aging. This effect has been observed in both animal models and in vitro studies.[2]
3. Neuroprotective Effects: Epitalon has been shown to stimulate gene expression and protein synthesis during neurogenesis, suggesting a role in neuronal differentiation and potential neuroprotective effects.[3]
4. Regulation of Melatonin Synthesis: Epitalon influences melatonin synthesis, which may help restore circadian rhythms and improve sleep patterns, particularly in aging individuals.[4]
5. Anti-Aging Effects: Studies have shown that Epitalon can increase the lifespan of various organisms, including mice and fruit flies, and may reduce age-related changes in hormone levels and immune function.[5-6]
6. Anti-Cancer Properties: Epitalon has demonstrated anti-carcinogenic effects in experimental models, potentially reducing the incidence of spontaneous tumors and inhibiting the development of leukemia.[5]
These findings suggest that Epitalon may have multiple beneficial effects related to aging, oxidative stress, and neuroprotection. However, further research, including clinical trials, is necessary to fully understand its mechanisms and potential therapeutic applications.
1. Antioxidant Properties of Geroprotective Peptides of the Pineal Gland. Kozina LS, Arutjunyan AV, Khavinson VKh. Archives of Gerontology and Geriatrics. 2007;44 Suppl 1:213-6. doi:10.1016/j.archger.2007.01.029.
2. Epitalon-Activated Telomerase Enhance Bovine Oocyte Maturation Rate and Post-Thawed Embryo Development. Ullah S, Haider Z, Perera CD, et al. Life Sciences. 2025;362:123381. doi:10.1016/j.lfs.2025.123381. New Research
3. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis During Neurogenesis: Possible Epigenetic Mechanism. Khavinson V, Diomede F, Mironova E, et al. Molecules (Basel, Switzerland). 2020;25(3):E609. doi:10.3390/molecules25030609.
4. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide With Promising Properties.
Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. International Journal of Molecular Sciences. 2025;26(6):2691. doi:10.3390/ijms26062691. New Research
5. Effect of Epitalon on Biomarkers of Aging, Life Span and Spontaneous Tumor Incidence in Female Swiss-Derived SHR Mice. Anisimov VN, Khavinson VKh, Popovich IG, et al. Biogerontology. 2003;4(4):193-202. doi:10.1023/a:1025114230714.
6. Effect of Epitalon on the Lifespan Increase in Drosophila Melanogaster.
Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV. Mechanisms of Ageing and Development. 2000;120(1-3):141-9. doi:10.1016/s0047-6374(00)00217-7.